Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration of colorectal cancer by inducing IL-8 expression

Exosomal KRAS mutation promotes the formation of tumor-associated neutrophil extracellular traps and causes deterioration of colorectal cancer by inducing IL-8 expression

Abstract Background Colorectal cancer (CRC) remains one of the leading causes of cancer-related death. The current study aimed to elucidate the mechanism by which exosomes carrying KRAS mutant contribute to neutrophil recruitment as well as the formation of the neutrophil extracellular trap (NET) in...

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Bibliographic Details
Main Authors: Anquan Shang, Chenzheng Gu, Chen Zhou, Yibao Yang, Chen Chen, Bingjie Zeng, Junlu Wu, Wenying Lu, Weiwei Wang, Zujun Sun, Dong Li
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cell Communication and Signaling
Subjects:
Colorectal cancer
KRAS mutant
IL-8
Exosome
Neutrophil extracellular trap
Neutrophil recruitment
Online Access:http://link.springer.com/article/10.1186/s12964-020-0517-1

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http://link.springer.com/article/10.1186/s12964-020-0517-1

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