Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status

Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status

Abstract Epithelial ovarian cancer is the most lethal gynecologic malignancy. In most women, it is diagnosed at an advanced stage, which largely explains the poor prognosis of this malignancy. Germline mutations of the genes BRCA1 and BRCA2, which encode proteins essential for the repair of double-s...

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Bibliographic Details
Main Authors: Angiolo Gadducci, Valentina Guarneri, Fedro Alessandro Peccatori, Graziana Ronzino, Giuseppa Scandurra, Claudio Zamagni, Paolo Zola, Vanda Salutari
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Ovarian Research
Subjects:
Bevacizumab
BRCA
DNA damage repair
Olaparib
Ovarian cancer
PARP inhibitor
Online Access:http://link.springer.com/article/10.1186/s13048-019-0484-6

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http://link.springer.com/article/10.1186/s13048-019-0484-6

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