6mer Seed Toxicity in Viral microRNAs

Summary: MicroRNAs (miRNAs) are short double-stranded noncoding RNAs (19-23 nucleotides) that regulate gene expression by suppressing mRNAs through RNA interference. Targeting is determined by the seed sequence (position 2-7/8) of the mature miRNA. A minimal G-rich seed of just six nucleotides is hi...

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Bibliographic Details
Main Authors: Andrea E. Murmann, Elizabeth T. Bartom, Matthew J. Schipma, Jacob Vilker, Siquan Chen, Marcus E. Peter
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S258900421930481X