Complete Cocrystal Formation during Resonant Acoustic Wet Granulation: Effect of Granulation Liquids

Complete Cocrystal Formation during Resonant Acoustic Wet Granulation: Effect of Granulation Liquids

The manufacturing of solid pharmaceutical dosage forms composed of cocrystals requires numerous processes during which there is risk of dissociation into parent molecules. Resonant acoustic wet granulation (RAG) was devised in an effort to complete theophylline–citric acid (THPCIT) cocrystal formati...

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Bibliographic Details
Main Authors: Ryoma Tanaka, Supisara Osotprasit, Jomjai Peerapattana, Kazuhide Ashizawa, Yusuke Hattori, Makoto Otsuka
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceutics
Subjects:
cocrystal
crystallization
solvate
hydrate
polymorphism
resonant acoustic mixer
Online Access:https://www.mdpi.com/1999-4923/13/1/56

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https://www.mdpi.com/1999-4923/13/1/56

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