CD154 and IL-2 signaling of CD4+ T cells play a critical role in multiple phases of CD8+ CTL responses following adenovirus vaccination.

CD154 and IL-2 signaling of CD4+ T cells play a critical role in multiple phases of CD8+ CTL responses following adenovirus vaccination.

Adenoviral (AdV) vectors represent most commonly utilized viral vaccines in clinical studies. While the role of CD8(+) cytotoxic T lymphocyte (CTL) responses in mediating AdV-induced protection is well understood, the involvement of CD4(+) T cell-provided signals in the development of functional CD8...

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Bibliographic Details
Main Authors: Channakeshava Sokke Umeshappa, Roopa Hebbandi Nanjundappa, Yufeng Xie, Andrew Freywald, Yulin Deng, Hong Ma, Jim Xiang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3465321?pdf=render

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http://europepmc.org/articles/PMC3465321?pdf=render

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