Endothelin-1 promotes survival and chemoresistance in chronic lymphocytic leukemia B cells through ETA receptor.

Endothelin-1 promotes survival and chemoresistance in chronic lymphocytic leukemia B cells through ETA receptor.

The endothelin axis, comprising endothelins (ET-1, ET-2 and ET-3) and their receptors (ET(A)R and ETBR), has emerged as relevant player in tumor growth and metastasis. Here, we investigated the involvement of ET-1/ET(A)R axis in chronic lymphocytic leukemia (CLL). CLL cells expressed higher levels o...

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Bibliographic Details
Main Authors: Rossana Maffei, Jenny Bulgarelli, Stefania Fiorcari, Silvia Martinelli, Ilaria Castelli, Vanessa Valenti, Davide Rossi, Goretta Bonacorsi, Patrizia Zucchini, Leonardo Potenza, Daniele Vallisa, Valter Gattei, Giovanni Del Poeta, Francesco Forconi, Gianluca Gaidano, Franco Narni, Mario Luppi, Roberto Marasca
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4046988?pdf=render

Internet

http://europepmc.org/articles/PMC4046988?pdf=render

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