Self-assembling HA/PEI/dsRNA-p21 ternary complexes for CD44 mediated small active RNA delivery to colorectal cancer

Self-assembling HA/PEI/dsRNA-p21 ternary complexes for CD44 mediated small active RNA delivery to colorectal cancer

Our previous work proved that sequence specific double strand RNA (dsRNA-p21) effectively activated p21 gene expression of colorectal cancer (CRC) cells and consequently suppressed CRC growth. However, efficient delivery system is a significant challenge to achieve sufficient therapy. In this study,...

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Bibliographic Details
Main Authors: Chen-Lin Feng, Yan-Xing Han, Hui-Hui Guo, Xiao-Lei Ma, Zhi-Qiang Wang, Lu-Lu Wang, Wen-Sheng Zheng, Jian-Dong Jiang
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Drug Delivery
Subjects:
colorectal cancer
ternary complexes
small active rna
hyaluronic acid
tumor targeted
Online Access:http://dx.doi.org/10.1080/10717544.2017.1386732

Internet

http://dx.doi.org/10.1080/10717544.2017.1386732

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