The Mechanism of Radiosensitization by YM155, a Novel Small Molecule Inhibitor of Survivin Expression, is Associated with DNA Damage Repair

The Mechanism of Radiosensitization by YM155, a Novel Small Molecule Inhibitor of Survivin Expression, is Associated with DNA Damage Repair

Background/Aims: Survivin, a member of the inhibitor of apoptosis protein family, is an attractive target for cancer therapy. We investigated the effects of YM155, a small molecule inhibitor of survivin expression, on the radiosensitivity of human non-small cell lung cancer (NSCLC) cell lines and el...

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Bibliographic Details
Main Authors: Songliu Hu, Songbin Fu, Xiangying Xu, Lin Chen, Jianyu Xu, Bin Li, Yuanyuan Qu, Hongyang Yu, Shan Lu, Wenxin Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
DNA-PKcs
DNA repair
Ku70
Phospho-histone H2AX
Survivin
Non-small cell lung cancer
Online Access:http://www.karger.com/Article/FullText/430245

Internet

http://www.karger.com/Article/FullText/430245

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