Imipramine blocks acute silicosis in a mouse model

Imipramine blocks acute silicosis in a mouse model

Abstract Background Inhalation of crystalline silica is associated with pulmonary inflammation and silicosis. Although silicosis remains a prevalent health problem throughout the world, effective treatment choices are limited. Imipramine (IMP) is a FDA approved tricyclic antidepressant drug with lys...

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Bibliographic Details
Main Authors: Rupa Biswas, Kevin L. Trout, Forrest Jessop, Jack R. Harkema, Andrij Holian
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Particle and Fibre Toxicology
Subjects:
Silica
Silicosis
Particles
Imipramine
Macrophage
Lysosome
Online Access:http://link.springer.com/article/10.1186/s12989-017-0217-1

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http://link.springer.com/article/10.1186/s12989-017-0217-1

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