N-acetyl-L-tryptophan attenuates hepatic ischemia-reperfusion injury via regulating TLR4/NLRP3 signaling pathway in rats

N-acetyl-L-tryptophan attenuates hepatic ischemia-reperfusion injury via regulating TLR4/NLRP3 signaling pathway in rats

The aim of this study was to investigate the changes of TLR4/NLRP3 signal during hepatic ischemia-reperfusion injury (HIRI) and to verify whether N-acetyl-L-tryptophan (L-NAT) protected hepatocytes by regulating the activation of TLR4/NLRP3 signal. We have established the rat HIRI model and H2O2-ind...

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Bibliographic Details
Main Authors: Yitong Pan, Shuna Yu, Jianxin Wang, Wanzhen Li, Huiting Li, Chen Bai, Yaxin Sheng, Ming Li, Chenchen Wang, Jiao Liu, Peitong Xie, Can Wang, Jiying Jiang, Jianguo Li
Format: Article
Language:English
Published: PeerJ Inc. 2021-08-01
Series:PeerJ
Subjects:
Hepatic ischemia-reperfusion injury
Pyroptosis
L-NAT
NLRP3
Online Access:https://peerj.com/articles/11909.pdf

Internet

https://peerj.com/articles/11909.pdf

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