mTOR Suppresses Macroautophagy During Striatal Postnatal Development and Is Hyperactive in Mouse Models of Autism Spectrum Disorders

mTOR Suppresses Macroautophagy During Striatal Postnatal Development and Is Hyperactive in Mouse Models of Autism Spectrum Disorders

Macroautophagy (hereafter referred to as autophagy) plays a critical role in neuronal function related to development and degeneration. Here, we investigated whether autophagy is developmentally regulated in the striatum, a brain region implicated in neurodevelopmental disease. We demonstrate that a...

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Bibliographic Details
Main Authors: Ori J. Lieberman, Veronica Cartocci, Irena Pigulevskiy, Maya Molinari, Josep Carbonell, Miguel Bellés Broseta, Michael R. Post, David Sulzer, Anders Borgkvist, Emanuela Santini
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
striatum
development
autophagy
mTOR
autism
valproic acid
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00070/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00070/full

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