Sevoflurane Inhibition of the Slowly Activating Delayed Rectifier K+ Current in Guinea Pig Ventricular Cells

Single ventricular cells were enzymatically isolated from guinea pig hearts and the effects of sevoflurane on the delayed rectifier K+ current were investigated by the patch clamp method. The rapidly (IKr) and slowly activating delayed rectifier K+ current (IKs) were isolated using chromanol 293B, a...

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Bibliographic Details
Main Authors: Shigehiro Shibata, Kyoichi Ono, Toshihiko Iijima
Format: Article
Language:English
Published: Elsevier 2004-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131932417X