The chimeric monoclonal antibody MHCSZ-123 against human von Willebrand factor A3 domain inhibits high-shear arterial thrombosis in a Rhesus monkey model

The chimeric monoclonal antibody MHCSZ-123 against human von Willebrand factor A3 domain inhibits high-shear arterial thrombosis in a Rhesus monkey model

Abstract Background SZ-123, a murine monoclonal antibody that targets the human von Willebrand factor (VWF) A3 domain and blocks the binding of collagen, is a powerful antithrombotic. In a Rhesus monkey model of thrombosis, SZ-123 had no side effects, such as bleeding or thrombocytopenia. Methods Th...

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Bibliographic Details
Main Authors: Shundong Ji, Miao Jiang, Bin Yan, Fei Shen, Yang He, Aini Wan, Lijun Xia, Changgeng Ruan, Yiming Zhao
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Journal of Hematology & Oncology
Subjects:
Thrombosis
Collagen
Von Willebrand factor (VWF)
Platelet
Platelet aggregation
Monoclonal antibody
Online Access:http://link.springer.com/article/10.1186/s13045-017-0475-2

Internet

http://link.springer.com/article/10.1186/s13045-017-0475-2

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