Altered inhibition and excitation in neocortical circuits in congenital microcephaly

Altered inhibition and excitation in neocortical circuits in congenital microcephaly

Congenital microcephaly is highly associated with intellectual disability. Features of autosomal recessive primary microcephaly subtype 3 (MCPH3) also include hyperactivity and seizures. The disease is caused by biallelic mutations in the Cyclin-dependent kinase 5 regulatory subunit-associated prote...

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Bibliographic Details
Main Authors: Sami Zaqout, Kathrin Blaesius, Yuan-Ju Wu, Stefanie Ott, Nadine Kraemer, Lena-Luise Becker, Marta Rosário, Christian Rosenmund, Ulf Strauss, Angela M. Kaindl
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Neurobiology of Disease
Subjects:
Cdk5rap2
Microcephaly
Neuronal differentiation
Synaptic transmission
Dendritic morphogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301226

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http://www.sciencedirect.com/science/article/pii/S0969996119301226

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