Spatial rank-based multifactor dimensionality reduction to detect gene–gene interactions for multivariate phenotypes

Spatial rank-based multifactor dimensionality reduction to detect gene–gene interactions for multivariate phenotypes

Abstract Background Identifying interaction effects between genes is one of the main tasks of genome-wide association studies aiming to shed light on the biological mechanisms underlying complex diseases. Multifactor dimensionality reduction (MDR) is a popular approach for detecting gene–gene intera...

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Bibliographic Details
Main Authors: Mira Park, Hoe-Bin Jeong, Jong-Hyun Lee, Taesung Park
Format: Article
Language:English
Published: BMC 2021-10-01
Series:BMC Bioinformatics
Subjects:
Fuzzy clustering
Gene–gene interaction
Multifactor dimensionality reduction
Spatial rank statistic
Online Access:https://doi.org/10.1186/s12859-021-04395-y

Internet

https://doi.org/10.1186/s12859-021-04395-y

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