Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells

Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells

Abstract Introduction Ewing's sarcoma is an aggressive childhood malignancy whose outcome has not substantially improved over the last two decades. In this study, combination treatments of the HSP90 inhibitor AUY922 with either the ATR inhibitor VE821 or the ATM inhibitor KU55933 were investiga...

Full description

Bibliographic Details
Main Authors: Christian Marx, Marc U. Schaarschmidt, Joanna Kirkpatrick, Lisa Marx-Blümel, Melisa Halilovic, Martin Westermann, Doerte Hoelzer, Felix B. Meyer, Yibo Geng, Katrin Buder, Hauke M. Schadwinkel, Kanstantsin Siniuk, Sabine Becker, René Thierbach, James F. Beck, Jürgen Sonnemann, Zhao-Qi Wang
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Cell & Bioscience
Subjects:
ATM
ATR
Ewing's sarcoma
HSP90
Endoplasmic reticulum (ER) stress
Apoptosis
Online Access:https://doi.org/10.1186/s13578-021-00571-y

Internet

https://doi.org/10.1186/s13578-021-00571-y

Similar Items