Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex

Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex

Astrocyte dysfunction may contribute to epileptogenesis and other neurological deficits in Tuberous Sclerosis Complex (TSC). In particular, decreased expression and function of astrocyte glutamate transporters have been implicated in causing elevated extracellular glutamate levels, neuronal death, a...

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Bibliographic Details
Main Authors: Ling-Hui Zeng, Adam W. Bero, Bo Zhang, David M. Holtzman, Michael Wong
Format: Article
Language:English
Published: Elsevier 2010-03-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
Seizure
Glia
GLT-1
Ceftriaxone
Epileptogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109003751

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http://www.sciencedirect.com/science/article/pii/S0969996109003751

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