Type 1 Sodium Calcium Exchanger Forms a Complex with Carbonic Anhydrase IX and Via Reverse Mode Activity Contributes to pH Control in Hypoxic Tumors

Type 1 Sodium Calcium Exchanger Forms a Complex with Carbonic Anhydrase IX and Via Reverse Mode Activity Contributes to pH Control in Hypoxic Tumors

Hypoxia and acidosis are among the key microenvironmental factors that contribute to cancer progression. We have explored a possibility that the type 1Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX1) is involved in pH control in hypoxic tumors. We focused on changes in intrace...

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Bibliographic Details
Main Authors: Veronika Liskova, Sona Hudecova, Lubomira Lencesova, Filippo Iuliano, Marta Sirova, Karol Ondrias, Silvia Pastorekova, Olga Krizanova
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
sodium calcium exchanger type 1
sodium proton exchanger type 1
carbonic anhydrase IX
hypoxic tumors
intracellular pH
Online Access:https://www.mdpi.com/2072-6694/11/8/1139

Internet

https://www.mdpi.com/2072-6694/11/8/1139

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