Overcoming Barriers for siRNA Therapeutics: From Bench to Bedside

Overcoming Barriers for siRNA Therapeutics: From Bench to Bedside

The RNA interference (RNAi) pathway possesses immense potential in silencing any gene in human cells. Small interfering RNA (siRNA) can efficiently trigger RNAi silencing of specific genes. FDA Approval of siRNA therapeutics in recent years garnered a new hope in siRNA therapeutics. However, their t...

Full description

Bibliographic Details
Main Authors: Muhammad Imran Sajid, Muhammad Moazzam, Shun Kato, Kayley Yeseom Cho, Rakesh Kumar Tiwari
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Pharmaceuticals
Subjects:
siRNA delivery systems
barriers to siRNA delivery
endosomal escape
reticuloendothelial system entrapment
renal clearance
off-target effects
Online Access:https://www.mdpi.com/1424-8247/13/10/294

Internet

https://www.mdpi.com/1424-8247/13/10/294

Similar Items