Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma

Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma

Hypoxia is a predominant feature in glioblastoma (GBM) and contributes greatly to its drug resistance. However, the molecular mechanisms which are responsible for the development of the resistant phenotype of GBM under hypoxic conditions remain unclear. To analyze the key pathways promoting therapy...

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Bibliographic Details
Main Authors: Yixing Gao, Bao Liu, Lan Feng, Binda Sun, Shu He, Yidong Yang, Gang Wu, Guoji E, Chang Liu, Yuqi Gao, Erlong Zhang, Bo Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
hypoxia
drug resistance
JUN
CEBPB
HDAC3
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00033/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00033/full

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