Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity

Within the last 3 years, genome-wide association studies (GWAS) have had unprecedented success in identifying loci that are involved in common diseases. For example, more than 35 susceptibility loci have been identified for type 2 diabetes and 32 for obesity thus far. However, the causal gene and va...

Full description

Bibliographic Details
Main Authors: Roger D. Cox, Christopher D. Church
Format: Article
Language:English
Published: The Company of Biologists 2011-03-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/4/2/155