Intratracheal instillation of high dose adenoviral vectors is sufficient to induce lung injury and fibrosis in mice.

Intratracheal instillation of high dose adenoviral vectors is sufficient to induce lung injury and fibrosis in mice.

Replication deficient adenoviruses (Ad) vectors are common tools in gene therapy. Since Ad vectors are known to activate innate and adaptive immunity, we investigated whether intratracheal administration of Ad vectors alone is sufficient to induce lung injury and pulmonary fibrosis.We instilled Ad v...

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Bibliographic Details
Main Authors: Qiyuan Zhou, Tianji Chen, Melike Bozkanat, Joyce Christina F Ibe, John W Christman, J Usha Raj, Guofei Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4281082?pdf=render

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http://europepmc.org/articles/PMC4281082?pdf=render

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