Deep Sequencing of MHC-Adapted Viral Lines Reveals Complex Recombinational Exchanges With Endogenous Retroviruses Leading to High-Frequency Variants

Deep Sequencing of MHC-Adapted Viral Lines Reveals Complex Recombinational Exchanges With Endogenous Retroviruses Leading to High-Frequency Variants

Experimental evolution (serial passage) of Friend virus complex (FVC) in mice demonstrates phenotypic adaptation to specific host major histocompatibility complex (MHC) genotypes. These evolved viral lines show increased fitness and virulence in their host-genotype-of-passage, but display fitness an...

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Bibliographic Details
Main Authors: Earl A. Middlebrook, Derek L. Stark, Douglas H. Cornwall, Jason L. Kubinak, Wayne K. Potts
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Genetics
Subjects:
recombination
ERV
host adaptation
serial passage
Friend virus complex
murine leukemia virus
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.716623/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.716623/full

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