Aromatic interactions with membrane modulate human BK channel activation

Aromatic interactions with membrane modulate human BK channel activation

Large-conductance potassium (BK) channels are transmembrane (TM) proteins that can be synergistically and independently activated by membrane voltage and intracellular Ca2+. The only covalent connection between the cytosolic Ca2+ sensing domain and the TM pore and voltage sensing domains is a 15-res...

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Bibliographic Details
Main Authors: Mahdieh Yazdani, Guohui Zhang, Zhiguang Jia, Jingyi Shi, Jianmin Cui, Jianhan Chen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
membrane anchoring
atomistic simulation
allosteric coupling
channel gating
hydrophobic dewetting
Online Access:https://elifesciences.org/articles/55571

Internet

https://elifesciences.org/articles/55571

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