Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis

Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis

Osteomyelitis is a chronic bone infection that is often treated with adjuvant antibiotic-impregnated poly(methyl methacrylate) (PMMA) cement spacers in multi-staged revisions. However, failure rates remain substantial due to recurrence of infection, which is attributed to the poor performance of the...

Full description

Bibliographic Details
Main Authors: Ryan P. Trombetta, Mark J. Ninomiya, Ihab M. El-Atawneh, Emma K. Knapp, Karen L. de Mesy Bentley, Paul M. Dunman, Edward M. Schwarz, Stephen L. Kates, Hani A. Awad
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Pharmaceutics
Subjects:
osteomyelitis
<i>Staphylococcus aureus</i>
sitafloxacin
rifampin
calcium phosphate
3D printing
drug delivery
1-stage revision
PMMA
Online Access:https://www.mdpi.com/1999-4923/11/2/94

Internet

https://www.mdpi.com/1999-4923/11/2/94

Similar Items