A Unique Human Immunoglobulin Heavy Chain Variable Domain-Only CD33 CAR for the Treatment of Acute Myeloid Leukemia

A Unique Human Immunoglobulin Heavy Chain Variable Domain-Only CD33 CAR for the Treatment of Acute Myeloid Leukemia

Acute myeloid leukemia (AML) remains a challenging pediatric and adult disease. Given the elevated expression of the CD33 antigen on leukemic blasts, therapeutic approaches to AML now feature the approved antibody drug conjugate (Mylotarg, GO) and investigational CART cell approaches incorporating C...

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Bibliographic Details
Main Authors: Dina Schneider, Ying Xiong, Peirong Hu, Darong Wu, Weizao Chen, Tianlei Ying, Zhongyu Zhu, Dimiter S. Dimitrov, Boro Dropulic, Rimas J. Orentas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Oncology
Subjects:
AML
lentiviral vector
CAR-T
CD33
VH
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00539/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00539/full

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