RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome

RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome

Multiple organ dysfunction syndrome (MODS) is a serious event that can occur following infection or tissue injury, and is partly mediated by histones released in circulation. Here, the authors develop aptamers that neutralise histones involved in MODS, and demonstrate efficacy in human cells and in...

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Bibliographic Details
Main Authors: Kevin T. Urak, Giselle N. Blanco, Shambhavi Shubham, Li-Hsien Lin, Justin P. Dassie, William H. Thiel, Yani Chen, Vijay Kumar Sonkar, Beilei Lei, Shubha Murthy, Wade R. Gutierrez, Mary E. Wilson, Jonathan A. Stiber, Julia Klesney-Tait, Sanjana Dayal, Francis J. Miller, Paloma H. Giangrande
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08030-y

Internet

https://doi.org/10.1038/s41467-018-08030-y

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