Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH

Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH

Background Non-alcoholic steatohepatitis (NASH) is a progressive liver disease characterized by hepatic steatosis, lobular inflammation and fibrosis. Acetyl-CoA carboxylase (ACC) isoform 1 and 2 involved in de novo lipogenesis (DNL) and fatty acid oxidation have been identified as a therapeutic targ...

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Bibliographic Details
Main Authors: Ying Lu, Xiaolan Su, Manyu Zhao, Qianru Zhang, Chuang Liu, Qinhuai Lai, Sijia Wu, Aiping Fang, Jinliang Yang, Xiaoxin Chen, Yuqin Yao
Format: Article
Language:English
Published: PeerJ Inc. 2019-12-01
Series:PeerJ
Subjects:
Transcriptome
RNA-Seq
Non-alcoholic steatohepatitis
Acetyl-CoA carboxylase inhibitor
Online Access:https://peerj.com/articles/8115.pdf

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https://peerj.com/articles/8115.pdf

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