Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology

Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology

Deregulation of the cholesterol pathway is an anomaly observed in human diseases, many of which have in common neurological involvement and unknown pathogenesis. In this study we have used Mevalonate Kinase Deficiency (MKD) as a disease-model in order to investigate the link between the deregulation...

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Bibliographic Details
Main Authors: Annalisa Marcuzzi, Elisa Piscianz, Marina Zweyer, Roberta Bortul, Claudia Loganes, Martina Girardelli, Gabriele Baj, Lorenzo Monasta, Claudio Celeghini
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:International Journal of Molecular Sciences
Subjects:
cholesterol pathway
apoptosis
neuroinflammation
mevalonate
mitochondria
neuronal death
Online Access:http://www.mdpi.com/1422-0067/17/3/365

Internet

http://www.mdpi.com/1422-0067/17/3/365

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