Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach

Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach

Abstract Background X-chromosomal genes contribute to sex differences, in particular during early development, when both X chromosomes are active in females. Double X-dosage shifts female pluripotent cells towards the naive stem cell state by increasing pluripotency factor expression, inhibiting the...

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Bibliographic Details
Main Authors: Oriana Genolet, Anna A. Monaco, Ilona Dunkel, Michael Boettcher, Edda G. Schulz
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Genome Biology
Subjects:
X chromosome
Gene dosage
Embryonic stem cells
Sex differences
Pluripotency
MAPK signaling
Online Access:https://doi.org/10.1186/s13059-021-02321-2

Internet

https://doi.org/10.1186/s13059-021-02321-2

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