Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter

Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter

Th22 cells constitute a recently described CD4+ T cell subset defined by its production of interleukin (IL)-22. The action of IL-22 is mainly restricted to epithelial cells. IL-22 enhances keratinocyte proliferation but inhibits their differentiation and maturation. Dysregulated IL-22 production has...

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Bibliographic Details
Main Authors: Daniel V. Lopez, Fatima A.H. Al-Jaberi, Nkerorema D. Damas, Brian T. Weinert, Urska Pus, Sara Torres-Rusillo, Anders Woetmann, Niels Ødum, Charlotte M. Bonefeld, Martin Kongsbak-Wismann, Carsten Geisler
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
Th22 cells
IL-22
IL-17
vitamin D
vitamin D receptor
vitamin D response element (VDRE)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.715059/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.715059/full

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