A carrier for non-covalent delivery of functional beta-galactosidase and antibodies against amyloid plaques and IgM to the brain.

A carrier for non-covalent delivery of functional beta-galactosidase and antibodies against amyloid plaques and IgM to the brain.

BACKGROUND: Therapeutic intervention of numerous brain-associated disorders currently remains unrealized due to serious limitations imposed by the blood-brain-barrier (BBB). The BBB generally allows transport of small molecules, typically <600 daltons with high octanol/water partition coefficient...

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Bibliographic Details
Main Authors: Gobinda Sarkar, Geoffry L Curran, Eric Mahlum, Teresa Decklever, Thomas M Wengenack, Anthony Blahnik, Bridget Hoesley, Val J Lowe, Joseph F Poduslo, Robert B Jenkins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3244419?pdf=render

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http://europepmc.org/articles/PMC3244419?pdf=render

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