Arterial Wall Stress Induces Phenotypic Switching of Arterial Smooth Muscle Cells in Vascular Remodeling by Activating the YAP/TAZ Signaling Pathway

Arterial Wall Stress Induces Phenotypic Switching of Arterial Smooth Muscle Cells in Vascular Remodeling by Activating the YAP/TAZ Signaling Pathway

Background/Aims: Increasing wall stress or biomechanical stretch experienced by arteries influences the initiation of atherosclerotic lesions. This initiation is mediated by Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which are both effectors of the Hi...

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Bibliographic Details
Main Authors: Yongshun Wang, Wei Cao, Jinjin Cui, Yang Yu, Yubo Zhao, Jian Shi, Jian Wu, Zhengyuan Xia, Bo Yu, Jingjin Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Vascular Remodeling
Arterial Smooth Muscle Cells
YAP/TAZ
Shear Stress
Cyclic Strain
Online Access:https://www.karger.com/Article/FullText/495376

Internet

https://www.karger.com/Article/FullText/495376

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