Mild traumatic brain injury produces neuron loss that can be rescued by modulating microglial activation using a CB2 receptor inverse agonist

Mild traumatic brain injury produces neuron loss that can be rescued by modulating microglial activation using a CB2 receptor inverse agonist

We have previously reported that mild TBI created by focal left-side cranial blast in mice produces widespread axonal injury, microglial activation, and a variety of functional deficits. We have also shown that these functional deficits are reduced by targeting microglia through their cannabinoid t...

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Bibliographic Details
Main Authors: Anton Reiner, Wei Bu, Huiling Ren, Yunping Deng, Nobel Del Mar, Natalie Hart Guley, Bob M Moore, Marcia G Honig
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Neuroscience
Subjects:
Cerebral Cortex
Striatum
basolateral amygdala
neuron loss
Traumatic brain injury (TBI)
neuron rescue
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00449/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00449/full

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