Genistein upregulates LDLR levels via JNK-mediated activation of SREBP-2

Background: Genistein has been proved in vitro and in vivo to lower LDLR level. It is also widely consumed and implicated for its anti-atherogenic effects. However, the molecular mechanism by which genistein lowers the LDL level is still unknown. Objective: To understand the anti-atherogenic molecul...

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Bibliographic Details
Main Authors: Medicia Kartawijaya, Hye Won Han, Yunhye Kim, Seung-Min Lee
Format: Article
Language:English
Published: Swedish Nutrition Foundation 2016-05-01
Series:Food & Nutrition Research
Subjects:
JNK
Online Access:http://www.foodandnutritionresearch.net/index.php/fnr/article/view/31120/46756