In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

The calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) activates CAMK1, CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of CAMKK2 is linked to several diseases, suggesting the utility of CAMKK2 inhibitors for oncological, metabolic and inflammatory indi...

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Bibliographic Details
Main Authors: Sean N. O’Byrne, John W. Scott, Joseph R. Pilotte, André da S. Santiago, Christopher G. Langendorf, Jonathan S. Oakhill, Benjamin J. Eduful, Rafael M. Couñago, Carrow I. Wells, William J. Zuercher, Timothy M. Willson, David H. Drewry
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
kinase
camkk2
sto-609
chemical probes
oncology
kinase inhibitors
Online Access:https://www.mdpi.com/1420-3049/25/2/325

Internet

https://www.mdpi.com/1420-3049/25/2/325

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