QNB: differential RNA methylation analysis for count-based small-sample sequencing data with a quad-negative binomial model

QNB: differential RNA methylation analysis for count-based small-sample sequencing data with a quad-negative binomial model

Abstract Background As a newly emerged research area, RNA epigenetics has drawn increasing attention recently for the participation of RNA methylation and other modifications in a number of crucial biological processes. Thanks to high throughput sequencing techniques, such as, MeRIP-Seq, transcripto...

Full description

Bibliographic Details
Main Authors: Lian Liu, Shao-Wu Zhang, Yufei Huang, Jia Meng
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Bioinformatics
Subjects:
Differential methylation analysis
m6A
Negative binomial distribution
RNA methylation
Small-sample size
Online Access:http://link.springer.com/article/10.1186/s12859-017-1808-4

Internet

http://link.springer.com/article/10.1186/s12859-017-1808-4

Similar Items