In vivo effects in melanoma of ROCK inhibition-induced FasL over-expression

In vivo effects in melanoma of ROCK inhibition-induced FasL over-expression

Ectopic Fas-ligand (FasL) expression in tumor cells is responsible for both tumor escape through tumor counterattack of Fas-positive infiltrating lymphocytes, and tumor rejection though inflammatory and immune responses. Our team has previously shown that RhoA GTPase and its effector ROCK kinases ne...

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Bibliographic Details
Main Authors: Iotefa eTeiti, Florie eBertrand, Christine ePich, Rémi eGence, Isabelle eLajoie-Mazenc, Philippe eRochaix, Gilles eFavre, Anne-Françoise eTilkin-Mariamé
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Oncology
Subjects:
Melanoma
immune response
FasL
ROCK
H1152
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00156/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00156/full

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