Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model

Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model

Abstract In neuroinflammatory disorders such as multiple sclerosis, the physiological function of the blood-brain barrier (BBB) is perturbed, particularly in demyelinating lesions and supposedly secondary to acute demyelinating pathology. Using the toxic non-inflammatory cuprizone model of demyelina...

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Bibliographic Details
Main Authors: Stefan A. Berghoff, Tim Düking, Lena Spieth, Jan Winchenbach, Sina K. Stumpf, Nina Gerndt, Kathrin Kusch, Torben Ruhwedel, Wiebke Möbius, Gesine Saher
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Acta Neuropathologica Communications
Subjects:
Blood-brain barrier
Demyelination
Gliosis
Astrocyte
Inflammatory mediators
Online Access:http://link.springer.com/article/10.1186/s40478-017-0497-6

Internet

http://link.springer.com/article/10.1186/s40478-017-0497-6

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