Betulin suppresses TNF-α and IL-1β production in osteoarthritis synovial fibroblasts by inhibiting the MEK/ERK/NF-κB pathway

Betulin suppresses TNF-α and IL-1β production in osteoarthritis synovial fibroblasts by inhibiting the MEK/ERK/NF-κB pathway

Osteoarthritis (OA) is characterized by the infiltration of a number of proinflammatory cytokines into the joint microenvironment. Betulin is a natural analogue of betulinic acid, a lupane-type pentacyclic triterpene that displays many important biological activities, including anti-inflammatory act...

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Bibliographic Details
Main Authors: Chin-Horng Su, Chih-Yang Lin, Chun-Hao Tsai, Hsiang-Ping Lee, Lun-Chien Lo, Wei-Chien Huang, Yang-Chang Wu, Ching-Liang Hsieh, Chih-Hsin Tang
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Journal of Functional Foods
Subjects:
Betulin
Osteoarthritis
TNF-α
IL-1β
ACLT
Proinflammatory cytokines
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621003789

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http://www.sciencedirect.com/science/article/pii/S1756464621003789

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