Distinct and overlapping functions of ptpn11 genes in Zebrafish development.

Distinct and overlapping functions of ptpn11 genes in Zebrafish development.

The PTPN11 (protein-tyrosine phosphatase, non-receptor type 11) gene encodes SHP2, a cytoplasmic PTP that is essential for vertebrate development. Mutations in PTPN11 are associated with Noonan and LEOPARD syndrome. Human patients with these autosomal dominant disorders display various symptoms, inc...

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Bibliographic Details
Main Authors: Monica Bonetti, Virginia Rodriguez-Martinez, Jeroen Paardekooper Overman, John Overvoorde, Mark van Eekelen, Chris Jopling, Jeroen den Hertog
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3988099?pdf=render

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http://europepmc.org/articles/PMC3988099?pdf=render

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