Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds

Brain-specific angiogenesis inhibitor (BAI) is an adhesion G protein-coupled receptor that acts through the ELMO/DOCK/Rac signaling pathway. Here the authors provide molecular insights into BAI/ELMO interactions by solving the crystal structure of the C-terminal cytoplasmic tail of BAI bound to the...

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Bibliographic Details
Main Authors: Zhuangfeng Weng, Chenghao Situ, Lin Lin, Zhenguo Wu, Jinwei Zhu, Rongguang Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07938-9