Cholinergic Transactivation of the EGFR in HaCaT Keratinocytes Stimulates a Flotillin-1 Dependent MAPK-Mediated Transcriptional Response

Cholinergic Transactivation of the EGFR in HaCaT Keratinocytes Stimulates a Flotillin-1 Dependent MAPK-Mediated Transcriptional Response

Acetylcholine and its receptors regulate numerous cellular processes in keratinocytes and other non-neuronal cells. Muscarinic acetylcholine receptors are capable of transactivating the epidermal growth factor receptor (EGFR) and, downstream thereof, the mitogen-activated protein kinase (MAPK) casca...

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Bibliographic Details
Main Authors: Sina Kühne, Wymke Ockenga, Antje Banning, Ritva Tikkanen
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:International Journal of Molecular Sciences
Subjects:
acetylcholine
muscarinic receptor
mitogen-activated protein kinase
cell proliferation
receptor tyrosine kinases
growth factor
keratinocytes
gene regulation
Online Access:http://www.mdpi.com/1422-0067/16/3/6447

Internet

http://www.mdpi.com/1422-0067/16/3/6447

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