Involvement of nucleophosmin (NPM1/B23) in assembly of infectious HPV16 capsids

We report that during assembly of HPV16 pseudovirus (PsV) the minor capsid protein, L2, interacts with the host nucleolar protein nucleophosmin (NPM1/B23). Exogenously-expressed L2 colocalized with NPM1, a complex containing both proteins, could be immunoprecipitated, and L2 could redirect to the nu...

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Bibliographic Details
Main Authors: Patricia M. Day, Cynthia D. Thompson, Yuk Ying Pang, Douglas R. Lowy, John T. Schiller
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Papillomavirus Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2405852115000117