Identification of universal and cell-type specific p53 DNA binding

Identification of universal and cell-type specific p53 DNA binding

Abstract Background The tumor suppressor p53 is a major regulator of the DNA damage response and has been suggested to selectively bind and activate cell-type specific gene expression programs. However recent studies and meta-analyses of genomic data propose largely uniform, and condition independen...

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Bibliographic Details
Main Authors: Antonina Hafner, Lyubov Kublo, Michael Tsabar, Galit Lahav, Jacob Stewart-Ornstein
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Molecular and Cell Biology
Subjects:
p53
ChIP-seq
Chromatin
DNA damage
Gene expression
Online Access:http://link.springer.com/article/10.1186/s12860-020-00251-8

Internet

http://link.springer.com/article/10.1186/s12860-020-00251-8

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