Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin

Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin

The efficacy of cisplatin-based chemotherapy in ovarian cancer is often limited by the development of drug resistance. In most ovarian cancer cells, cisplatin activates extracellular signal-regulated kinase1/2 (ERK1/2) signalling. Phosphoprotein enriched in astrocytes (PEA-15) is a ubiquitously expr...

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Bibliographic Details
Main Authors: Shahana Dilruba, Alessia Grondana, Anke C. Schiedel, Naoto T. Ueno, Chandra Bartholomeusz, Jindrich Cinatl Jr, Katie-May McLaughlin, Mark N. Wass, Martin Michaelis, Ganna V. Kalayda
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
pea-15
ovarian cancer
cisplatin sensitivity
Online Access:https://www.mdpi.com/2073-4409/9/2/515

Internet

https://www.mdpi.com/2073-4409/9/2/515

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