Macrophages/Microglia Represent the Major Source of Indolamine 2,3-Dioxygenase Expression in Melanoma Metastases of the Brain

Macrophages/Microglia Represent the Major Source of Indolamine 2,3-Dioxygenase Expression in Melanoma Metastases of the Brain

The manifestation of brain metastases in patients with advanced melanoma is a common event that limits patient's survival and quality of life. The immunosuppressive properties of the brain parenchyma are very different compared to the rest of the body, making it plausible that the current succe...

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Bibliographic Details
Main Authors: Dayana Herrera-Rios, Sadaf S. Mughal, Sarah Teuber-Hanselmann, Daniela Pierscianek, Antje Sucker, Philipp Jansen, Tobias Schimming, Joachim Klode, Julia Reifenberger, Jörg Felsberg, Kathy Keyvani, Benedikt Brors, Ulrich Sure, Guido Reifenberger, Dirk Schadendorf, Iris Helfrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
melanoma
brain metastases
IDO
immune checkpoint molecules
tumor-associated macrophages
immunogenic microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00120/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00120/full

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