Epigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells

Epigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells

The use of human mesenchymal stem cells (hMSCs) in clinical applications requires large-scale cell expansion prior to administration. However, the prolonged culture of hMSCs results in cellular senescence, impairing their proliferation and therapeutic potentials. To understand the role of microRNAs...

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Bibliographic Details
Main Authors: Yi-deun Jung, Seul-Ki Park, Dayeon Kang, Supyong Hwang, Myoung-Hee Kang, Seung-Woo Hong, Jai-Hee Moon, Jae-Sik Shin, Dong-Hoon Jin, Dalsan You, Joo-Yong Lee, Yun-Yong Park, Jung Jin Hwang, Choung Soo Kim, Nayoung Suh
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Redox Biology
Subjects:
Cellular senescence
Mitochondrial oxidative stress
microRNAs
DNMT3A
SOD2
Human mesenchymal stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309216

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http://www.sciencedirect.com/science/article/pii/S2213231720309216

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