Modulating glutathione thiol status alters pancreatic β-cell morphogenesis in the developing zebrafish (Danio rerio) embryo

Modulating glutathione thiol status alters pancreatic β-cell morphogenesis in the developing zebrafish (Danio rerio) embryo

Emerging evidence suggests that redox-active chemicals perturb pancreatic islet development. To better understand potential mechanisms for this, we used zebrafish (Danio rerio) embryos to investigate roles of glutathione (GSH; predominant cellular redox buffer) and the transcription factor Nrf2a (Nf...

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Bibliographic Details
Main Authors: Archit Rastogi, Emily G. Severance, Haydee M. Jacobs, Sarah M. Conlin, Sadia T. Islam, Alicia R. Timme-Laragy
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Redox Biology
Subjects:
Pancreas
Nfe2l2
Antioxidant defenses
Islet
Redox
Embryonic development
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309939

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http://www.sciencedirect.com/science/article/pii/S2213231720309939

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