Anti-hypercholesterolemic Effects and a Good Safety Profile of SCM-198 in Animals: From ApoE Knockout Mice to Rhesus Monkeys

Anti-hypercholesterolemic Effects and a Good Safety Profile of SCM-198 in Animals: From ApoE Knockout Mice to Rhesus Monkeys

Although several lipid-lowering agents have been introduced for the treatment of atherosclerosis (AS), currently marketed medications have not solved the problem completely. This study aims to investigate the effects of leonurine (SCM-198) on dyslipidemia in mammals with ApoE knockout (ApoE-/-) mice...

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Bibliographic Details
Main Authors: Rinkiko Suguro, Siyao Chen, Di Yang, Zunyuan Yang, Lei Miao, Weijun Wu, Wen Zeng, Xinhua Liu, Yi Zhun Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Pharmacology
Subjects:
leonurine
SCM-198
atherosclerosis
dyslipidemia
Rhesus monkeys
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01468/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01468/full

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